| Host: | HEK293 cells |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Erythropoietin/EPO-NO-tag protein was developed from hek293 cells and has a target region of NO-tag. For use in research applications. |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.07-0.27 ng/mL, corresponding to a specific activity of 3.70 × 106~1.43× 107 units/mg. |
| Gene Symbol: | EPO |
| Gene ID: | 2056 |
| Uniprot ID: | EPO_HUMAN |
| Immunogen Region: | Ala28-Arg193 |
| Immunogen: | Recombinant Human Erythropoietin/EPO Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala28-Arg193) of human Erythropoietin/EPO (Accession #NP_000790.2) fused with no additional amino acid. |
| Function | Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. |
| Protein Name | Erythropoietin Epoetin |
| Database Links | Reactome: R-HSA-1234158 Reactome: R-HSA-9006335 Reactome: R-HSA-9027276 Reactome: R-HSA-9027277 Reactome: R-HSA-9027283 Reactome: R-HSA-9027284 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Erythropoietin protein Epoetin protein EPO protein |
Information sourced from Uniprot.org