| Host: | HEK293 cells |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CCL8/MCP-2-N-hFC protein was developed from hek293 cells and has a target region of N-hFC. For use in research applications. |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCL8 |
| Gene ID: | 6355 |
| Uniprot ID: | CCL8_HUMAN |
| Immunogen Region: | Gln24-Pro99 |
| Immunogen: | Recombinant Human CCL8/MCP-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Pro99) of human CCL8/MCP-2 (Accession #NP_005614.2) fused with and a hFc tag at the N-terminus. |
| Post Translational Modifications | N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. |
| Function | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. |
| Protein Name | C-C Motif Chemokine 8 Hc14 Monocyte Chemoattractant Protein 2 Monocyte Chemotactic Protein 2 Mcp-2 Small-Inducible Cytokine A8 Cleaved Into - Mcp-2(6-76 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 8 protein Hc14 protein Monocyte Chemoattractant Protein 2 protein Monocyte Chemotactic Protein 2 protein Mcp-2 protein Small-Inducible Cytokine A8 Cleaved Into - Mcp-2(6-76 protein CCL8 protein MCP2 protein SCYA10 protein SCYA8 protein |
Information sourced from Uniprot.org